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In-bed postures offer valuable information about an individual's sleep quality and overall health conditions, particularly for patients with sleep apnea. However, current in-bed posture classification systems lack privacy-friendly and easy-to-install options. Furthermore, existing solutions do not consider variations between patients and are typically trained only once, neglecting the utilization of time consistency and unlabeled data from new patients. To address these limitations, this paper builds on a seismic sensor to introduce a novel sleep posture framework, which comprises two main components, namely, the Multi-Granularity Supervised Contrastive Learning (MGSCL) module and the ensemble Online Adaptation (oa) module. Unlike most existing contrastive learning frameworks that operate at the sample level, MGSCL leverages multi-granular information, operating not only at the sample level but also at the group level. The oa module enables the model to adapt to new patient data while ensuring time consistency in sleep posture predictions. Additionally, it quantifies model uncertainty to generate weighted predictions, further enhancing performance. Evaluated on a dataset of 100 patients collected at a clinical research center, MGSCLoa achieved an average accuracy of 91.67% and an average F1 score of 91.53% with only 40 seconds of labeled data per posture. In a Phase 2 evaluation with 11 participants over 13 nights in home settings, the framework reached an average accuracy of 85.37% and a weighted F1 score of 83.59% using just 3 minutes of labeled data per common posture for each participant. These results underscore the potential of seismic sensor-based in-bed posture classification for assessing sleep quality and related health conditions. 

In automated sleep monitoring systems, bed occupancy detection is the foundation or the first step before other downstream tasks, such as inferring sleep activities and vital signs. The existing methods do not generalize well to real-world environments due to single environment settings and rely on threshold-based approaches. Manually selecting thresholds requires observing a large amount of data and may not yield optimal results. In contrast, acquiring extensive labeled sensory data poses significant challenges regarding cost and time. Hence, developing models capable of generalizing across diverse environments with limited data is imperative. This paper introduces SeismoDot, which consists of a self-supervised learning module and a spectral-temporal feature fusion module for bed occupancy detection. Unlike conventional methods that require separate pre-training and fine-tuning, our self-supervised learning module is co-optimized with the primary target task, which directs learned representations toward a task-relevant embedding space while expanding the feature space. The proposed feature fusion module enables the simultaneous exploitation of temporal and spectral features, enhancing the diversity of information from both domains. By combining these techniques, SeismoDot expands the diversity of embedding space for both the temporal and spectral domains to enhance its generalizability across different environments. SeismoDot not only achieves high accuracy (98.49%) and F1 scores (98.08%) across 13 diverse environments, but it also maintains high performance (97.01% accuracy and 96.54% F1 score) even when trained with just 20% (4 days) of the total data. This demonstrates its exceptional ability to generalize across various environmental settings, even with limited data availability. 

In this study, we introduce BedDot, the first contact-free and bed-mounted continuous blood pressure monitoring sensor. Equipped with a seismic sensor, BedDot eliminates the need for external wearable devices and physical contact, while avoiding privacy or radiation concerns associated with other technologies such as cameras or radars. Using advanced preprocessing techniques and innovative AI algorithms, we extract time-series features from the collected bedseismogram signals and accurately estimate blood pressure with remarkable stability and robustness. Our user-friendly prototype has been tested with over 75 participants, demonstrating exceptional performance that meets all three major industry standards, which are the Association for the Advancement of Medical Instrumentation (AAMI) and Food and Drug Administration (FDA), and outperforms current state-of-the-art deep learning models for time series analysis. As a non-invasive solution for monitoring blood pressure during sleep and assessing cardiovascular health, BedDot holds immense potential for revolutionizing the field. 

Abstract Purpose Obstructive sleep apnea (OSA) results in systemic intermittent hypoxia. By one model, hypoxic stress signaling in OSA patients alters the levels of inflammatory soluble cytokines TNF and IL6, damages the blood brain barrier, and activates microglial targeting of neuronal cell death to increase the risk of neurodegenerative disorders and other diseases. However, it is not yet clear if OSA significantly alters the levels of the soluble isoforms of TNF receptors TNFR1 and TNFR2 and IL6 receptor (IL6R) and co-receptor gp130, which have the potential to modulate TNF and IL6 signaling. Methods Picogram per milliliter levels of the soluble isoforms of these four cytokine receptors were estimated in OSA patients, in OSA patients receiving airways therapy, and in healthy control subjects. Triplicate samples were examined using Bio-Plex fluorescent bead microfluidic technology. The statistical significance of cytokine data was estimated using the nonparametric Wilcoxon rank-sum test. The clustering of these high-dimensional data was visualized using t -distributed stochastic neighbor embedding (t-SNE). Results OSA patients had significant twofold to sevenfold reductions in the soluble serum isoforms of all four cytokine receptors, gp130, IL6R, TNFR1, and TNFR2, as compared with control individuals ( p  = 1.8 × 10 −13 to 4 × 10 −8 ). Relative to untreated OSA patients, airways therapy of OSA patients had significantly higher levels of gp130 ( p  = 2.8 × 10 −13 ), IL6R ( p  = 1.1 × 10 −9 ), TNFR1 ( p  = 2.5 × 10 −10 ), and TNFR2 ( p  = 5.7 × 10 −9 ), levels indistinguishable from controls ( p  = 0.29 to 0.95). The data for most airway-treated patients clustered with healthy controls, but the data for a few airway-treated patients clustered with apneic patients. Conclusions Patients with OSA have aberrantly low levels of four soluble cytokine receptors associated with neurodegenerative disease, gp130, IL6R, TNFR1, and TNFR2. Most OSA patients receiving airways therapy have receptor levels indistinguishable from healthy controls, suggesting a chronic intermittent hypoxia may be one of the factors contributing to low receptor levels in untreated OSA patients.